Poulin and theil

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Web1 Oct 2024 · Poulin and Theil (PT) initially proposed a tissue:plasma partition coefficient prediction method that accounts for dissolution into water and nonspecific binding to … Web1 Oct 2024 · The Poulin and Theil (2009) method led to good V ss predictions, but required in vivo data (K pu muscle) (Graham et al., 2012). More recently, Chan et al. (2024) …

A priori prediction of tissue:plasma partition coefficients …

WebThe standard calculation method present in the modeling program was adopted to estimate the cellular permeability. The Poulin and Theil model was used for the estimation of tissue plasma partition coefficients. 36. Elimination WebP. Poulin, F. Theil Published 2000 Biology Journal of pharmaceutical sciences The tissue:plasma (P (t:p)) partition coefficients (PCs) are important drug-specific input … chainlink jali

Prediction of Human Distribution Volumes of Compounds in …

Web18 Sep 2015 · Accordingly, the Poulin & Theil-Homogeneous model that most accurately predicted V ss and profile shape in dog was used for the prediction of human V ss. … Web27 Sep 2008 · These algorithms or their predictions of partition and distribution coefficients have been integrated within PBTK models to predict the inhalation kinetics of a number of … WebPatrick Poulin 1 , Frank-Peter Theil. Affiliation 1 [email protected]; PMID: 19455625 DOI: 10.1002/jps.21759 Abstract The parameters characterizing tissue … chainlink jpy

Development and Evaluation of a Physiologically Based …

WebPrediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution. In drug discovery and nonclinical development the volume of … Web1 May 2002 · The in vivo P t:p s for tissue:plasma ratios were calculated with established tissue composition-based equations for which the principles and assumptions are well … chainlink halalWeb18 Sep 2015 · The Poulin & Theil-Homogeneous model gave the closest estimate of V ss in dog. Using the Kp values predicted by the Poulin & Theil-Homogeneous model and the observed CL as input, the intravenous PK profile in dog was well simulated (Fig. 1a). The ratio of predicted AUC value to observed mean value was 1.1. chainlink junkie

"WebPATRICK POULIN, FRANK-PETER THEIL Non-Clinical Development-Drug Safety, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland … " - Poulin and theil

Poulin and theil

Application of physiologically based pharmacokinetic modeling in …

WebP. Theil, Non-clinical Safety, Roche Computational Biology – Basel 2004 Suggested integrated PBPK modeling(Theil et. al. Toxicol. Letters 138 (2003) 29-49) … WebPoulin & Theil The approach developed by Poulin and Theil considers the cell lipid subcompartment as mainly consisting of phospholipids with a lipophilicity-hydrophobicity …

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Web12 Mar 2009 · P. Poulin, and F. P. Theil. A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic … Web12 Mar 2009 · PBPK models are composed of many compartments corresponding to the different tissues of the body, e.g., adipose, bone, brain, gut, heart, kidney, liver, lung, muscle, skin, and spleen, which are connected by the circulating blood system (arterial and venous). A schematic of a PBPK model is shown in Fig. 1.

Web1 Jan 2000 · Poulin and Theil first reported methods to estimate k tp in the lean and adipose tissues [2] based on the assumption that the unbound drug is distributed homogeneously into lipid and water in each ... WebP Poulin 1 , F P Theil. Affiliation 1 Department of Drug Metabolism & Pharmacokinetics, F. Hoffmann-La Roche, Ltd., Pharma Research, CH-4070 Basel, Switzerland. …

WebPoulin, P., & Theil, F. P. (2000). A priori prediction of tissue: Plasma partition coefficients of drugs to facilitate the use of physiologically‐based pharmacokinetic models in drug discovery. Journal of pharmaceutical sciences, 89 (1), 16-35. Prerequisites Microsoft Windows 7 or later Microsoft Office 2010 or later Microsoft .NET 4+ Download Web14 Jul 2024 · Poulin and Theil (PT) initially proposed a tissue:plasma partition coefficient prediction method that accounts for dissolution into water and non-specific binding to …

WebPoulinTheil. An Excel add-in for prediction of partition coefficient. Poulin, P., & Theil, F. P. (2000). A priori prediction of tissue: Plasma partition coefficients of drugs to facilitate the …

WebIn fact, the method was applied to 123 drugs covering a broad range of physicochemical (lipophilicity and ionization) and biochemical (plasma protein binding) properties. These … chainlink keskusteluWebAbstract. Tissue:plasma (P (t:p)) partition coefficients (PCs) are important parameters describing tissue distribution of drugs. The ultimate goal in early drug discovery is to … chainlink jobs salaryWeb1 Feb 2024 · Volumes of distribution have been predicted according to the tissue composition equations proposed by Poulin and Theil (2000, 2002) and Poulin et al. (2001 ), as corrected by Berezhkovskiy (2004) and equations proposed by Rodgers et al. (2005) and Rodgers and Rowland (2006, 2007 ). chainlink kopenWebP. Poulin, F. Theil Published 2000 Biology Journal of pharmaceutical sciences The tissue:plasma (P (t:p)) partition coefficients (PCs) are important drug-specific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. chainlink link marinesWebP. Poulin, F. Theil; Published 2002; Biology; Journal of pharmaceutical sciences; In drug discovery and nonclinical development the volume of distribution at steady state (V(ss)) of each novel drug candidate is commonly determined under in vivo conditions. Therefore, it is of interest to predict V(ss) without conducting in vivo studies. chainlink kiminWebNational Center for Biotechnology Information chainlink koinWeb18 Mar 2024 · Prediction of tissue-prediction partition coefficient using Poulin&Theil method Usage Kpcoeff_PT(logP, pKa, fup, BP = 1, type = 1, dattype = 0) Arguments. logP: … chainlink kurssi